Tumor Samples & in vivo Models

Tumor Samples:

  • AML patient cells
  • MDS patient cells
  • CMML patient cells
  • AML PDX
  • breast samples
  • lung samples
  • liver samples 
  • pancreatic samples
  • brain samples
  • melanoma

Tumor Models:

  • AML
  • MDS
  • CMML
  • Pancreatic Cancer (PDAC)
  • Melanoma

List of Infection & Cancer Models

MHH Research Groups

MHH Research Group Patient Material Animal Models Established Methods
AG Heuser / Thol AML, MDS AML, ALL, CMML Genetic and xenograft mouse models, loss-of-function screens, genetic and phenotypic characterization of hematopoiesis; sensitive detection of mutations (NGS-MRD)
AG Vogel / Saborowski HCC, CCA, precision oncology CCA, HCC, PDAC, PDX, chronic liver injury models (FAH, MDR2, DEN, NASH/ASH) Genetic and xenograft models, organoids, multipsectral imaging, murine hepatobiliary surgical techniques (e.g.partial hepatectomy, intrabiliary injection); Investigator- Initiated trials (hepatobiliary)
AG Falk NSCLC, explanted lung tissue as comparator (Coop. Jonigk) NSCLC Fresh lung tissue preparation für FACS, T cell assass, single cell mRNA Seq (Seqwell, 10X CITE Seq), Microenvorinment (Luminex)
AG Feuerhake Biopsy cohorts (translational biomarker studies) in collaboration with multiple clinical trials including TNBC, HCC, CAC, Sarcoma, … EBV + DLBCL / PTLD (in collaboration with AG Stripecke), NSCLC (in collaboration with Charles River, Freiburg) Highly multiplexed IHC (Vectra Polaris), computational & digital pathology approaches to spatially resolved TILs / TAM immunophenotyping
AG Göhring Myeloid neoplasia (AML, MDS, CMML, MPN…)   Targeted RNA sequencing, DNA sequencing (exom; custom panel for haematologic neoplasia), telomere length measurement (PCR, flow cytometry, FISH), cytogenetics (chromosome analysis and FISH); all methods are accredited

UMG Research Groups

UMG Research Group Patient Material Animal Models Established Methods
AG Chapuy Genomically characterized cohorts of aggressive lymphoma, total ~800 primary tumors
H. pylori
Preclinical models of aggressive lymphoma Lymphoma /Tumor (Epi)Genomics, chromatin biology, functional screens, modelling incl. PDX, analyses of cell death pathways, PD-1 mediated immune escape
AG Papantonis PDAC organoids / Glioblastoma GSCs   Epigenomics (ChIP/ATAC/RNA-seq), single cell genomics, chromosome conformation (Hi-C), genome scaffolding, DNA/RNA FISH, CRISPR editing
AG Ellenrieder PDAC Transgenic, snygeneic and PDX PDAC models; NASH/NAFLD models (Western-diet, TAA) RNA/ChIP-Seq, DNA damage detection (e.g Comet), primary Hepatocyte isolation, Er-stress signaling, CRISPR Cas9
AG Haase, INDIGHO3 AML, MDS, MPN   Chromosome banding analysis, FISH, Multicolor FISH, NGS, cytogenetics and NGS of sorted (MACS/FACS) cell populations
AG Heßmann PDAC Diverse transgenic PDAC models, syngeneic PDAC models, PDAC PDX models Chromatin immunoprecipitation, diverse biochemical analysis, mouse monitoring

Contact

Please fill out the contact form. We will get in touch with you as soon as possible.