Genome dynamics encompasses a myriad of critical processes including disrupted replication, mitosis, epigenetics, transcriptional control, and DNA repair. These fundamental mechanisms play pivotal roles in tumor progression, therapeutic responses, and the emergence of resistance. Moreover, genome dynamics can modulate immunoregulation through factors like DNA damage and distinct epigenetic pathways. Our objective is to holistically comprehend both - Genome Dynamics and Immunoregulation - in order to tailor novel therapies effectively.

Stratification-based therapy in cancer is a treatment approach that tailors interventions to the unique characteristics of individual patients and their tumors. This approach maximizes treatment efficacy while minimizing potential side effects. The Stratification-based Therapy program includes biomarker development using large patient cohorts and biobanked materials, with a strong emphasis on clinical registries and biomaterial sampling through the Lower Saxony Unified Biobank (LSUB). The approach aims to identify patient subgroups for targeted clinical trials using also data science and imaging technologies.

CCC-N’s Cancer Prevention and Outcomes Research program combines early detection, treatment of pre-cancerous lesions, and outcome as well as implementation evaluation, including psycho-social, palliative, and supportive care. It uses imaging, pathology, and genomic sequencing data for early detection and large registries and epidemiological methodologies to analyze and optimize patient care.